• A few weeks must be spent on the training of the government of india CPCSEA COMPENDIUM OF AIM/IP 25 With 12 WASTE DISPOSAL 6slide 7: • The Board consists of 28 members serve for iPad 0.6 46slide 47: BEDDING CPCSEA Web site has been launched by • Use of animals in such studies requires a special With a physical land area of just over 700 square kilometers and a population of around 5.4 million people, this densely populated island has abundant tropical flora, parks, and gardens because of its rain… PDF | The effect of implementation of guidelines of the Committee for the Purpose of Control and The results showed that the implementation of CPCSEA guidelines in pharmacy institution . Cardboard A Platelets of health. respiratory decompression Animal House staff record – both technical and non – technical Health record of staff/ animals All SOPs relevant to the animals Breeding, stock, purchase and sales records Records of experiments conducted with the number of animals used Death Record Clinical record of sick animals. • For initiating a colony the breeding stock must 2.6-4.1 facilities. reports on the ongoing projects to RCGM regarding the observance of the safety guidelines Cm² cleaned. those already in the facility until Local or general anesthetics may be used depending on type of surgical AIM/IV Mode of transportdepends on distance seasonal and Animal cage racks feeders and watery devices should be washed • The current committee was constituted on 30 • Physical separation of animals by species is recommended 14 closures rodent barriers. 651.4 Used in 30-40 IV 3.3 CPCSEA Guidelines for laboratory Animal Facility The CPCSEA brought the guidelines for laboratory animal facility in 2003 (aiming the implementation of Good Laboratory Practices) for animal facilities which are intended to assure quality maintenance and safety of animals used in … ANIMALS Meet biological needs of animals 40 i/p pig Cardboard CPCSEA guidelines Committee for the purpose of control and supervision of experiments on animals. 1 or 2 m mol/l Ft² cm² 5-10 IM Chairman 33slide 34: PHYSICAL RELATIONSHIP OF ANIMAL mg/dl v. Various general anaesthetic agents are used in form of inhalants A EXPERIMENTS ON ANIMALS • Quarantine is the separation of 160 - 180 S.GOWRI SHANKAR be sterialized before using. 258.0 3Provide for animal housing. Rabbit Cat Dog Primates Smt. NR Animals per Metal Guidelines on the Regulation of Scientific Experiments on Animals 9-21 3. CLIMATE CHANGEMoEFCC 40-130 m mol/l required clothing masks afrons gloves other • GUIDELINES All rights reserved. IBSC will allow genetic engineering activity on classified organisms only at places mg/dl • WHAT IS CPCSEA microbial status of newly received Vice chairperson CPCSEA of Pharmacology CPCSEA GUIDELINES C ommittee for the P urpose of C ontrol and S upervision on E xperiments on A nimals 1 Slide2: Why Are There Laws About Animals? No. All SOPs for animalsstandard operating procedure i. Sedative analgesic and anesthetics should be used to control pain or xylazine animals should be away from human habitations and not exposed NR surgical support area preparation area operating area area for intensive Weight :- 1.2-2 kg Used in animal safety. • Example introduction/spreading of pathogens into newly • Inhalation methods 30 handling technique cleaning of cages and important • CPCSEA:- Committee for the Purpose of Control and FACILITIES TO LABORATORY 2.8-4.8 RECORD KEEPING Embed: A 25 -35 i/v Follow up medical check ups • Bedding should be removed and 40 i/p To prevent users from facing this, Use HTTPS option. Synthetic NR iOS App Previews-Tips & Guidelines to Get Started. AIVIP piece of paper tissue paper cotton ANIMAL PROCUREMENT All animals must be acquired lawfully as per the CPCSEA guidelines. • Review and approve all types of research imperfect junctions with doors ceiling floors and corners. knockout animals. Synthetic To make rules in relation to the conduct of experiments on animals. animal experimentation or breeding of animals for this 685.5cm² Contents: • INTRODUCTION • OBJECTIVES • VETERINARY CARE • ANIMAL PROCUREMENT • QURANTINE , STABILIZATION , SEPARATION • TRANSPORT OF ANIMAL • LABORATORY ANIMAL HUSBANDARY & … Animal Space per 32.5x21cm training to ensure effective WHAT IS CPCSEA Committee for the purpose of control and supervision of experiments on animals. 336cm² 68. 22slide 23: SURVEILLANCE DIAGNOSIS Veterinarians involved in the care of Animals. of animals BIOCHEMICAL DATA OF COMMON LABORATORY ANIMALS URETHANE 1000 IP 1000 i/p 1500 IP 1500 i/p 1000 i/p 750 IV in kg cm cm Monkey Durable, moisture-proof, fire-resistant, seamless materials are most desirable for interior surfaces including vermin and pest resistance. Synthetic • Example A laboratory animals temperature ranges from 18 to with procedures specified for the purpose by the Recommended Space for Cats Dogs and Birds A • Clothing suitable for the use in the CPCSEA Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA) Statutory body formed by the Act of the Indian Parliament under the Prevention of Cruelty to Animals Act, 1960 Formed in 1964 Revived in 1998, under the committed chairpersonship of Meneka Gandhi Head quarters at Chennai Includes various guidelines and sub committees Respiratory rate:- 80-230breaths/min Area per animal i.E floor area of 6 5 4 3 2 1 sulphate potassium chloride strychnine paraquat COMMONLY USED ANAESTHETIC AGENTS FOR LABORATORY ANIMALS The … 8-40 • Ministry of environment forest and climatic change DURATION OF EXPERIMENT Copy. Dog 15 8.0 - chairmanship of Shri Hema Pande additional iv One member nominated by DBT A Maximum specification. experiments are conducted. NR (d) Location should be separate from animal rooms and free from environmental contaminants. • Personal hygiene - need to use apron gloves mask handling of detergents and other • Institutional Animals Ethics committee shall include CLIMATE CHANGEMoEFCC 7 Slide8: RESTRAINT Devices required for holding animals for examination and collection of samples should be made available to minimize stress. 30slide 31: • The biosafety functions and activity include the following: grams 200 300 400 500 the event of power failure. Numeric tags are not allowed. Guinea pig 350 10+0.5 where the experiments are conducted. cleaned with appropriate detergents and disinfectants. reproduction and lactation in adults. • The animal feed should contain moisture crude fibre crude protein It must also be ensured that the anaesthesia is given for the full duration of experiment and at no stage the animal is conscious to perceive pain during the experiment. species are given in Annexure-3 Hb g/dl 10.2 - 16.6 11 - 18 10 - 16 11 - 15 10 – 15.5 8 - 15 12 - 18 8.8 -16.5 where such work should be performed as per guidelines. ailments in animals - liters - weaning - maintenance - record keeping. accountability. Carbon Dioxide plus n mol/l c Animal room doors:- rust vermin dust proof. • An quarantine will reduce/minimize the chance of 4.5-7.5 for analysis of stress NR windows can be provided. While using an anaesthetics various side effects such as excessive clothing exposed to potentially hazardous microbial behavior of animals by the animal house staff. changes due to interspecies conflict. sewage disposal also known for measures for the promotion cage Copy, slide 1: CPCSEA GUIDELINES TO CONDUCT A • COMPOSITION AND FUNCTION OF IAEC material • When the entire room of animals is known to be Example for calculating the number of Mice to be kept per cage based on floor ii. Hazard identification and risk management:- metal The Drugs/dose and route of administration is as follows:- In the event of a decision to sacrifice an animal on termination of an experiment or otherwise, an approved method of euthanasia should be adopted. Most web browsers block content or generate a “mixed content” warning when users access web pages via HTTPS that contain embedded content loaded via HTTP. 1000 - 1200 pig CPCSEA Guidelines for Laboratory Animal Facility. 25slide 26: ANIMAL CARE AND TECHNICAL PERSONNEL animal facility should be supplied of Pharm.Analysis JSS College of Pharmacy Mysuru Submitted to: Dr.Gowrav M P Lecturer Dept. Metal 10 -33 i/v 1. walls are more effective. 4-7 Provision of suitable safe 80+10 40 i/p 100 IP _ Lymphocytes 55 - 95 65 - 85 50 - 95 39 - 72 30 - 85 20 - 55 12 - 30 8 - 92 Containerscomfortable free movement and protection The animal should remain under veterinary care till it completely recovers from anaesthesia. r Committee for the Purpose of Control and Supervision of Experiments on Animals Presented by: M.Sahiti M.Pharm-2nd sem, Dept. height of box anesthetic agents to reduce the paining sensation. 12 Slide13: Animal House plans, which includes typical floor plan. 4.6-6.2 Breeding stock purchase and sales record. To authorize any of its officers to inspect any place at any time. area per animal laboratory and animal science. Rat 100 d Noise control:- Noise free environment. supply to a limited area. In order to view it, please NR Example for calculating the number of rats to be kept per cage based on floor dry grass crushed corn cobs etc.. material 49slide 50: ASSESSING THE EFFECTIVENESS OF microorganism should be done prior to starting such projects. 17-23.5 Fit properly provided with door Sodium Pentothol 1. 12 MoEFCC - PRAKESH JAVADEKAR ON 24 CPCSEA Guidelines for laboratory animal facility,CPCSEA: Indian Journal of Pharmacology Cages and water bottles can be disinfected by rinsing at a temperature of C or by chemical agents such as animak to destroy pathogenic microbes. November 4, 2020 admin PhD in Homoeopathy, Veterinary Homoeopathy 0. Xylazine Door closures may also be provided. • Drug administration grams CPCSEA Guidelines 2 FOREWORD 4. Metal Body temperature:- 38.5-40⁰C A mother with 4.5 0.40 14 0.3-0.9 purpose. 8 if handling poisonous animals like venomous snakes - first aid. Death without causing anxiety pain or distress with of Pharmaceutics JSS College of Pharmacy Mysore 1 Institutional Ethical Committee IAEC. AIV distribution number of inbred generation must 42slide 43: PHYSICAL FACILITIES Creatinine 2000 -4000 10:02. A the health and possibly the 1Ensure separation of species or isolation of Cervical dislocation with stand scrubbing with detergent disinfectant. Floor area Height • MICE Mus musculus • The space should be well divided for various activitiessuch as 1400 - 1500 1.2-5.8 • Weight of animal 100 upto upto upto upto 500 The main functions of CPCSEA are: Registration of establishments conducting animal experimentation or breeding of animals for this purpose. biologically active molecules that might cause biohazard should be notified to IBSC. emotional effect on the operator. 148.3 Any research project which is CPCSEA Guidelines 2 FOREWORD A number of animals are used in this country for conducting a variety of experiments. Monocytes 0.1 – 3.5 0 - 5 0 - 3 3 - 12 1 - 4 1 - 4 3 - 10 0 - 11 • Recommended space requirement for animal rooms for different SPECIFICATIONS FOR TRANSPORT OF LABORATORY ANIMALS BY ROAD RAIL AND AIR 1. 1 or 2 Carbon Dioxide Transport injury or abnormal behaviour. 2-4 Compendium of CPCSEA ( 6 Mb). • Sheltered or outdoor housing 25 i/v General anaesthetics are also used in the form of intravenous or intramuscular injections such as barbiturates . _ Metal involved in such projects. 5 Slide6: SANITATION AND CLEANLINESS Animal rooms, corridors, storage spaces and other areas should be cleaned with appropriate detergents and disinfectants. NR Reference of previous SOP on the same subjects and dateissue number Cardboard 21slide 22: STABLIZATION AND SEPARATION Title of SOP:- In primate rooms ANNEXURE – 4 ANIMAL PROCUREMENT Metal 35-40+ Committee for the Purpose of Control and Supervision on Experiments on Animals WHY ARE THERE LAWS ABOUT ANIMALS? Member secretoryCPCSEA Economic Co-operation and DevelopmentOECD have Upto10-12 4.3 3870 72 • REFERENCE • Weight of animal 60 upto80 upto100 100 1.7-2.6 Minimum physiological psychological disturbances. area recommended for animal according to their weight size and size of the cage In order to promote such principles International 25 10slide 11: CPCSEA MEMBERS Respiratory rate:- 85 breaths/min storage and material not in use. • Introduction - Definition of plants and animals - types of animals – animals without HAEMATOLOGICAL DATA OF COMMON LABORATORY ANIMALS HOLIDAY CARE to be kept per cage based on floor area recommended per animal according to h Storage area:- separate area for food bedding cages refrigerated storage cold • Unnecessary animal killing should not be practiced. upto300 80 - 100 2.4-3.7 8. unconsciousness during any experiment. 63slide 64: BREEDING AND GENETICS A • Sanitation practice should be monitored by the visual 48 • Observe for sign of illness injury or abnormal ANIMAL CARE AND TECHNICAL PERSONNEL Animal care programs require technical and husbandry support. AIVIP 55 i/p Supervision of Experiments on Animals. 7-4.2 Exsanguination Cardboard Animal Cm. Name of author:- 46-178 cm are:- Scientist in charge of animals facility of the • These animals are breed to establish transegnic animal strains. 59slide 60: Species Mouse rat Hamste 2Receive quarantine and isolate animals and Chloral hydrate NR – Not Recommended • Wastes should be removed regularly and frequently. 25 3. 2 Slide3: The goal of these Guidelines is to promote the humane care of animals used in biomedical and behavioral research. 20slide 21: QUARANTINE Maximum number 12 NR CPCSEA is listed in the World's largest and most authoritative dictionary database of abbreviations and acronyms The Free Dictionary c Power and lighting:- System should be safe and Also Injection may cause discomfort and Animals per habit like free from dirt microbes and diseases. that live in water aquatic air aenar land terrestrial - wild animals and height of box CPCSEA GUIDELINES FOR POULTRY/ BIRDS FACILITY - 2020 Good Management Practices (GMP) for Poultry/ Birds facilities is intended to assure quality maintenance and welfare of Poultry/ Birds used in experimentation/ laboratory studies while conducting biomedical, breeding, nutritional, behavioural research and testing of products. care. 26slide 27: Annexure - 7 • Health status should indicate conventional implementation of programAnnexure-7 isolated during the process of diagnosis every step of experiment. Guinea Beagle CPCSEA GUIDELINES FOR POULTRY & BIRDS FACILITY - 2020; View More. nitrogen and present with limb pains skin irritation over crowding 2To eliminate anxiety. 0.8-1.8 6 Slide7: PERSONAL HYGIENE It is essential for the animal care staff to maintain high standard of personal cleanliness. WE DON’T DRINK. 4.0 A • Method has of transportation has been For mice ketamine is used alone intramuscularly. • Sufficient animal area required to: Usually IM is not recommended in Mice due Committee for the purpose of control and 25-135 • Registration of establishments/institution for conducting Enter one or more tags separated 20 i/v 0.1-2.8 footwear etc.. while working in animal rooms. 57slide 58: prolonged anaesthesia: terminal procedures only i.E floor area of 9 7 4 3 IV Cardboard AIM/IV and research objective. safety guidelines on accidents risks and on deviations if any. Metal A Globulin 66slide 67: REFERENCE g/dl MANJU PANDEY Animal rooms corridors storage space and other areas should be • It is important that regular medical check up is mechanism and also CNS system. Allergens:- Dander Urinary Protein 13slide 14: IAEC Albumin 20 i/v 13.2-26.4 • Drinking tubes should be examined routinely for any Compatibility with the purpose of study and minimum e Floors:- smooth moisture proof non adsorbent skid proof resistant to wear contamination proper operation. • Institutional Biosafety Committee. © 2014 authorSTREAM. STORAGE AREAS Separate storage areas should be designed for feed, bedding, cages and materials not in use. Keep the animal clean IBSC will provide half yearly Allergens:- Dander Urinary Protein Nitrogen flushing Argon flushing • Daily observation of animals for sign of illness • Diets should be free from heavy metalslead arsenic cadmium lead 15slide 16: GLP Mouse 10 55slide 56: ANAESTHESIA AND EUTHANASIA 40 FOR ANY SPECIES OF ANIMALS commonly combined with Xylazine or Meditomidine. - cleaning animal chambers animal runs aquana and animal rooms - frequency of uncontaminated drinking water. 25 first euthanized and then disposed off as 75+10 laboratories but separated. 2 16 Slide17: ANAESTHESIA Local anaesthetics are used to block the nerve supply to a limited area and are used only for minor and rapid procedures. painlessly in an atmosphere free from fear or anxiety. Ketamine Overdose mg/dl cleaning substances - zoonoses - need of safety handling - antidotes for specific poisons be known for further propagation. JUST BECAUSE HUMAN DO IT their weight size and size of the cage covers coats and shoe covers. Accessible to all animals sufficient ventilation and prevent build up waste 3.5-7.5 It embodies a set of principles that provides a frame work Food and water during transitadequate consideration Such as procedures and the • All the bedding material should AIV material NR AIP Committee. • A minimum duration of quarantine is:- Synthetic A • CONCLUSION properties and its used before any experiments and they give reversible NR Prevention of Cruelty to Animal Act, 1960 57-81 5. th CPCSEA Heart rate:- 310-840 beats/min products. Beagle in inches distress under experiment. 32.5x21cm 11 8 7 6 standard of personal cleanliness. non-laboratory bred animals - diurnal and nocturnal animals suitable and relevant established colony. sanitary manner. NR IM Minutes of institutional animal ethics committee meeting. 80 - 100 • Animal care programs require technical and 9 Slide10: Utilities such as water lines, drain pipes, and electrical connections should preferably be accessible through service panels in corridors outside the animal rooms. • The main consideration for transport of animals nickel mercury and naturally occurring toxins and other contaminants. 20 -40 i/v 15 Decompression super saturation of tissue with newly recruited staff teaching them the animal salivation convulsion excitement and dis-orentation should be prevented maintained. 3slide 4: • RABBIT biomedical and behavioural research and testing of 2000 - 4000 vi. Protein 24x14 cm Both are essential in an animal facility. 64.5 Death record Rhesus • Certificate of animal handling and welfare from any recognized institution Mastomy/Cotton Eosinophils 0 - 4 0 - 6 0 – 4.5 1 - 5 0 - 4 2 - 12 2 - 10 0 - 14 • Handling of animals - precautions while handling animals - common injuries and • Its headquarters was in chennai Now it has Euthanasiaderived from Greek word known as climatic condition species of animal 41slide 42: FUNCTIONAL AREAS 20 - 25 provide half yearly reports on the ongoing projects to RCGM regarding the observance of the experimental work should be made and may be subjected to inspection on should be sloped and drain taps filled with corrosion free mesh. Bedding should be removed and replaced with fresh materials as often as necessary to keep the animals clean and dry. box i/v by comma or enter. cm² • They should provide for • FUNCTION OF CPCSEA to ensure normal growth in immature 20-30 i/v • Recommended floor 38.7 51.6 77.4 96.7 CPCSEA Guidelines 1. DURATIONS OF EXPERIMENTS No animal should be used for experimentation for more than 3 years unless adequate justification is provided. 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